Congrats to Dr. Xu Zhang for her new manuscript on bioRxiv! Xu successfully integrated two separate extracellular electron transfer pathways controlled by different sensing modules into E. coli. Along with an agnostic algorithm she developed, this platform is capable of simultaneously sensing different heavy metals in urban water samples and transmitting a 2-bit binary readout. This is an important step forward in the informational capacity of bioelectronic sensors. Read more here!
Congratulations to Carol De Groote Tavares for passing her Admission to Candidacy exam! Carol studies electrogenetics in Lactiplantibacillus plantarum and is a real credit to the program. Read about our group’s work on extracellular electron transfer in L. plantarum here.
We’re happy to announce that Alanna Stull has passed her Masters thesis defense! Her research focused on controlling the structure and properties of engineered living materials. She modulated cell surface display through environmental factors and brought great insight into our materials. We’re excited to see what the next phase of her career brings!
We’re excited to share that Dr. Sara Molinari will joining the Fishell Department of Bioengineering at the University of Maryland as an incoming professor this summer! Her lab will bridge synthetic biology and material science to develop multifunctional engineered living materials for health and environmental applications. Keep an eye out as she builds her new group!
Ha Chau (Chloe) Nguyen and Robyn Alba have joined our group for their Ph.D. research. Chloe is in the Rice U.’s Systems, Synthetic, & Physical Biology Program and will be exploring the fundamental mechanisms of biomaterial formation. Robyn is in the Biochemistry & Cell Biology Program and will be creating living biosensors with bioelectronics. We’re so pleased to have them on the team!
Dr. Joe Tolar has successfully defended his PhD! His dissertation presentation covered “Expanding the Understanding of Extracellular Electron Transfer Mechanisms and the Physiological Impacts in Gram-Positive Bacteria” and you can read about his work here. He will be joining LevitasBio next.
Olivia Suggs has joined our group to work on allosteric protein switches as part of our Bioelectronics research. Olivia has a Bachelors in Biochemistry from Spelman College and is in the Biochemistry and Cell Biology Ph.D. program at Rice. We’re excited to have her on board!
We toasted to Esther and all the other NSF Graduate Research Fellowship Program recipients (with cake!) at Rice U. on Nov. 3. This fellowship is highly selective and we are very proud of Esther for her achievement. Support for a student like Esther is a big win for the field of engineered living materials!
Congratulations Lin, Josh, and Xu on their publication in Nature! This endeavor overcame challenges in biology and material science to create a specific, rapid bioelectronic sensor. With a detection time of minutes, this technology enables real-time monitoring of low concentration contaminants in water before they become irreversible, and is substantially faster and cheaper than fluorescence-based biosensors and liquid chromatography monitoring. To achieve this, the team engineered a synthetic electron transfer chain that pulls in proteins from four different organisms into E. coli, includes a post-translational gate to overcome rate limitations, and encapsulates the cells and electrode in conductive nanomaterials to improve signal to noise ratios. Proof of concept was demonstrated on thiosulfate and the endocrine disruptor 4-hydroxytamoxifen in environmental water samples, but the concept is applicable to a wide array of contaminants. Spanning the labs of Caroline Ajo-Franklin, Joff Silberg, and George Bennett, between Lawrence Berkeley National Lab and Rice University, this was truly a collaborative effort (our favorite kind)!
Check out the publication here, as well as Rice U’s write up of the project and the video below!
We’re seeking a collaborative, curious post-doc to join our Biomaterials team. As we’re a very multidisciplinary group, the position is open to those with backgrounds in biochemistry, bioengineering, materials science, microbiology (C. crescentus experience a plus!), molecular biology, or related field. The main qualification is a strong interest in engineered living materials and their applications! Check out the flyer below for more information and contact us.